We meet the Stratford sisters, Kat and Bianca, two very different people with very different views in life. They start at a new high school Padua High School with one thing in common, they both know strategy is the key. Kat wants to save the world and get out of high school as fast as she can, while Bianca wants to climb the ladder of high school popularity as fast as possible. Can each sister find happiness after getting off to a very rocky start?.
Bianca arranges a charity event for the cheerleading squad to impress Chasity. But her plan ends up raising more questions than money. Will Bianca get her flowers? Will Cameron ever get the guts to express his feelings? While Bianca waits for her carnations to arrive, Kat deals with a stalker and wonders in secret whether Patrick will send her a carnation.
Bianca's determination to get to a party with some of the coolest kids in school leads her to turn for help to Cameron who, of course, is perfectly willing to do whatever she needs. But it also could get her in trouble with her dad, who has forbidden her from attending the party. Will she be successful in her party pursuit?
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After Bianca falsely tells Chastity that she's dating an older guy to try to rid herself of her goody two-shoes reputation, Chastity sees Bianca "canoodling" with her geometry teacher and instantly starts the rumor around school that the two are dating. What happens when Bianca's attempt at being popular ends up turning her into the subject of some really juicy gossip?.
Determined to become an active environmentalist, Kat enrolls in shop class to convert her gas-guzzling car into a biodiesel vehicle. As the only girl in the class, Kat realizes that she needs to do more than fix cars to break the stereotype that girls can do anything boys can do. Will she be able to show the guys up in class, including Patrick Verona?.
Bianca and her new friend Dawn ask Cameron to help them with a new web reality show, so that Bianca can go in a shopping trip with Chastity. In order to get more viewers the girls realize that they need to be a little more adventurous. How far will they go to raise the money? Meanwhile, Kat complains about the grading system in one of her classes. Luckily for Kat, the school counselor has a personal vendetta against this particular teacher. In the end, the whole experience leads Kat to some self-realizations that she did not expected.
Bianca tries to us another opportunity to impress Chastity, when local residents suffer a bushfire and are relocated to Padua High. She tries to find a private room for Chastity in the school. Meanwhile, Patrick tries to have a moment alone with Kat to confess his feelings, but with the panic of the fire his chances might be ruined. They finally find a moment alone together in the school rooftop. Can Patrick get to tell her how feels?.
When Bianca gets asked to Padua High's Fall Fling by Beau Bradley, the captain of the soccer team, she sets out to convince Patrick to take Kat to the dance since their father has prohibited Bianca from dating until Kat does. Will Patrick give in to Bianca's plea?
Meanwhile, Cameron overhears Beau talking about taking Bianca to a hotel after the dance, so he puts into action a plan that will help keep a watchful eye over her and thwart any advances by Beau.
When Daddy's away his girls will play! Dr. Walter heads out of town that is and Kat and Bianca throw a house party that has both girls getting wild in their own way. While Patrick tries to clear the air with Kat, Bianca believes she's on the verge of becoming a legend. And Cameron... eats some "loaded" watermelon.
Padua High is about to become a battle ground when Kat, our ever liberal-minded activist, (along with sidekick Mandella) stages a walkout at when the school enforces a new, much stricter, security policy and dress code (school uniforms). Will she get excited when someone breaks out the chains?
Meanwhile, Bianca is sneaking around with a new fling and Cameron is finding it hard to get over the girl that he's been smitten with since the moment he met her.
In the mid-season premiere episode, Kat and Patrick are caught skipping school and both get suspended. How will Kat deal with a suspension after learning it might ruin her GPA, potentially destroying her dream to get into a prestigious college? Meanwhile, Bianca has her own problems after a secret make-out session with Joey is caught on video. Will Chastity watch the security tape before Bianca gets the chance to erase the evidence?.
Dr. Stratford wants Kat to invite Patrick over dinner and a healthy helping of interrogation. Meanwhile, all the cheerleaders freeze Bianca out, and Chastity says there's just one way she can have all her friends back.
Kat and Bianca both go on dates. Chastity doesn't. And somehow, nothing goes according to plan.
Kat tries to institute Meatless Mondays to change the world for the better. She is joined by Blank a british handsome guy and Patrick is jealous. Meanwhile, Bianca is determined to find Cameron a girlfriend but Cameron is finding hard to just be friends with Bianca. Walter decides to start dating again and joins an online dating service.
Bianca, tries to take Padua Hight's talent show until Chastity steels her song. Then right before going on stage, Chastity has tecnical difficulties and her mom tells her to drop out of the show. Will Chastity perform or will Bianca win the talent show and the grand prize of a walk-on role on "Make It or Break It"? Meanwhile, Cameron performs a magic act with a stage-struck Kat at his side.
Patrick starts to act more mysterious than usual and Kat thinks he has done something bad, while Joey wants to be in "The Next Biggest Poser" a male modeling reality TV show. Kat then spies on Patrick with the help of Cameron.
It's movie night at Padua High, and Bianca sets Cameron up on a date with Dawn so that they can double date with her and Joey. Meanwhile Kat is upset that Patrick told her she can date anyone she likes, so she decides to accept Blank's date night invitation. Patrick doesn't deal well with seeing Kat with the other guy, while Walter hits it off with the school counselor, and romance ensues.
Kat and Patrick make a major relationship decision. Walter asks the school counselor, Mrs. Tharpe out on a date, and Cameron's best friend Michael, comes out of the closet. Meanwhile, Bianca plans a fancy dinner party at home for her friends, and Joey gets a callback from "Biggest Poser".
Kat and Bianca discover that Walter is dating their school counselor, Darlene, and Kat decides to study abroad in Nepal, to try to get over Patrick. Bianca has to deal also with missing Joey while he is sequestered at the "Biggest Poser" house. Meanwhile, Cameron writes a love poem to Dawn, to express his love for her.
Kat decides to run for student body president after she learns William (Blank) is running unopposed. However, someone sabotages her video presentation and Kat ends up being humiliated. Bianca learns that playing nice is not always the best option.