When a mysterious stranger, Martin (Tyler Hoechlin), wanders into the Camden home and spends the day with the family everyone assumes he is Simon's friend. Meanwhile, a disheveled, Rabbi Glass (Richard Lewis) stops by to confide in Eric that he caught his wife (Loraine Newman) kissing another man and discusses about splitting up. Kevin feels emasculated after being attacked and injured by a woman during a domestic disturbance call and goes on medical leave. His attitude toward Lucy changes drastically as he worries that Lucy isn't attracted to him anymore. Plus, Simon is concerned that no one seems to care that he's leaving for college in a couple of days. Lastly, Ruthie and Peter struggle with a school project.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.