Bud is enraged when he finds out that his daughter Becky is engaged to J.C., Ernesto's nephew who just graduated from college. Meanwhile, a staunch anti-immigration law is passed which eventually leads to J.C'.s deportation, much to Bud's delight.

Bud fights to get a border wall constructed using confiscated drug money, only to have the wall destroy the economy, leaving him jobless. He then begins smuggling immigrants under the wall to make ends meet .

The reverend of Bud's megachurch asks Bud to lure Ernesto, the town's biggest church donor, away from the local Mexican Catholic church, to help fill their coffers. Ernesto is seduced by the glitziness of the church, and the reverend schemes to bring over all the other Mexican residents by "Hispandering", to Bud's horror. Bud and Ernesto team up to restore the status quo, but their plan backfires.

Bud becomes the high school football coach after the previous coach is forced out of the job by the local redneck fans. Bud, desperate to win, discovers a secret weapon - an illegal immigrant whom he sees gracefully and skillfully run across the border. Of course, this kid also happens to be the No. 1 drug mule in Mexico.

As Bud and Janice prepare to consummate their yearly anniversary sex, Maria's sister has a baby, which tips the Mexifornia population from white majority to Latino majority. So, Bud decides he needs to have a baby to counteract the number shift.

Ernesto attempts to get J.C. into the "real world" by forcing him to work on his crew. J.C. is appalled at what he believes are terrible working conditions and goes on strike, causing a rift in the Gonzalez family and in J.C'.s relationship with Becky.
Meanwhile, Bud is stalked by an ostrich that he decides is his "spirit animal".

Janice is forced to get a job as Ernesto's housekeeper when she secretly spends 5 on an American Gal doll for Gert and maxes out the credit card on accessories, so Gert plots revenge against the American Gal company while Bud plans to get Janice fired.

Bud helps a Mexican "Bud" look-alike sneak over the border, so he can take a break from his own life.

Gert's unhealthy eating causes her to have a heart attack during the Little Miss Mexifornia Pageant. Unable to afford the surgery in America, Bud takes her to Mexico to have her arteries unblocked and heart repaired.
Meanwhile, Ernesto and Maria put Pepito on medication that makes him behave, but they don't like the side effects.

When a wildfire threatens Mexifornia, all residents are required to evacuate. However, Bud refuses to leave his house, which catches fire, and Ernesto must come to the rescue to save him.

Meanwhile J.C. and Becky decide to take a break from their relationship and see other people in order to explore what it's like to date before committing to each other

Ernesto and Placido are thrilled that their favorite TV show, "La Fiesta Noche", will be filming in Mexifornia. The Buckwalds and Gonzalezes both get tickets to the taping, but Bud's anger at the spectacle causes him to be called onto the stage. Much to everyone's surprise, the audience loves him and he becomes a big star in the Mexican community

Janice secretly maxes out her credit card in the purchase of an American Gal doll and accessories and takes a job as Ernesto's housekeeper to earn some extra cash. Bud, however puts in motion a plan to get her fired, while Gert seeks revenge on the American Gal company.

When El Coyote is moved to the No. 1 spot on the "Most Wanted" list, Bud and Barracuda goballoonning for him: Bud because he let him slip across the border; Barracuda because he seeks to regain the top slot on the list. Meanwhile, Ruiz wants to free El Coyote so that an attractive waitress will see him as "more Mexican".