Dr. Oliver Wolf reluctantly accepts a job at Bronx General Hospital where he's forced to work with a team of interns as they treat a mother who can no longer recognize her children.

When a high school girls' basketball coach faces a debilitating illness, Dr. Wolf must help her reconnect with her body before it's too late. Ericka and Dana treat a frat boy who sees dragons.

A member of a biker gang seeks out Dr. Wolf's help as he grapples with life-threatening memory loss. The interns are tasked to help a young girl struggling with mysterious seizures.

When a bloody bride stumbles into Bronx General, Wolf goes to extreme measures in a race against the clock to save her and her missing husband. Ericka and Jacob must find a reason for their John Doe patient not to get transferred.

Dr. Wolf and the team must help a Marine grapple with mysterious symptoms before the birth of his child.

Dr. Wolf and the interns go back to high school to treat a group of pregnant teenagers.

Dr. Wolf and the team perform their most experimental treatment yet: a brain-computer interface implantation in their John Doe patient's brain.

When an elderly woman is brought in with signs of dementia, Dr. Wolf investigates whether she's suffering from a neurological disorder or having a late-in-life awakening. Dr. Pierce grapples with a chilling discovery about one of her patients.

When an artist refuses to paint for his upcoming show, Dr. Wolf and his team must figure out why. Dr. Pierce goes into uncharted territory with a patient.