Dr. Amy Larsen's life is upended by a traumatic crash that erases seven years' worth of memories, putting a strain on her colleagues, her family, and herself.

While at the hospital recovering, Amy (Molly Parker) can't help but insert herself into her roommate's case. Meanwhile, all the other doctors and nurses have to adjust to the once formidable Chief now being the patient.

Amy is allowed to return to work under strict guidelines and teams up with TJ to treat a patient suffering from mysterious liver problems. Sonya and Jake help an elderly couple navigate the final chapter of their love story.

Amy must confront who she has become after the tragedy that struck her family seven years ago. Sonya and TJ disagree on how to treat a sick Marine, and Amy and Jake make a life-changing discovery about an Alzheimer's patient.

Amy and Sonya endeavor to help a teen in need of a bone marrow transplant and his younger brother whose own health issues jeopardize his disability to donate. Jake deals with a fainting bride and her worried groom. Michael struggles with a secret he's been keeping.

It's a race against time as Amy and Jake try to uncover the cause of a unique patient's worsening condition. Gina treats a quirky hypochondriac, and Amy makes a shocking discovery about her pre-accident love life.

Amy helps Sonya with a deeply troubling personal matter which forces them to take undeniable risks; Richard deals with a family situation; Jake and TJ debate the moral implications of a diagnosis.

Amy and Richard reconnect while treating a patient whose diagnosis is not at all what it seems. A real life romcom comes to Westside Hospital, bringing love to the forefront of everyone's mind.

Amy, finally allowed to practice medicine again without supervision, struggles to diagnose her most complicated patient yet: TJ's Dad. Sonya and Jake treat a single mom who's reluctant to stay in the hospital. Richard tires to contain the truth about Dixon.

A mass casualty event requires all hands on deck at Westside Hospital. Amidst the chaos, Gina deals with a devastating revelation and Amy's forced to confront her demons.