Dr. Amy Larsen's life is upended by a traumatic crash that erases seven years' worth of memories, putting a strain on her colleagues, her family, and herself.

While at the hospital recovering, Amy can't help but insert herself into her roommate's case. Meanwhile, all the other doctors and nurses have to adjust to the once formidable Chief now being the patient.

Any is allowed to return to work under strict guidelines and teams up with TJ to treat a patient suffering from mysterious liver problems. Sonya and Jake help an elderly couple navigate the final chapter of their love story.

Amy must confront who she has become after the tragedy that struck her family seven years ago. Sonya and TJ disagree on how to treat a sick Marine, and Any and Jake make a life-changing discovery about an Alzheimer's patient.