Sensing their time in Florence is coming to an end, Bedelia Du Maurier and Hannibal consider their parting as Hannibal plans for his final stand. Meanwhile, Will Graham and Jack Crawford reunite, but Jack remains uncertain about Will's true loyalty. Back in the States, Mason Verger hungrily makes plans for Hannibal's capture, while Alana Bloom and Margot Verger makes plans of their own for Mason.
Will Graham is a gifted criminal profiler who is on the hunt for a serial hugger with the FBI. Graham's unique way of thinking gives him the astonishing ability to empathize with anyone - even psychopaths. He seems to know what makes them tick. But when the mind of the twisted hugger he's pursuing is too complicated for even Will to comprehend, he enlists the help of Dr. Lecter, one of the premier psychiatric minds in the country.
Armed with the uncanny expertise of the brilliant doctor, Will and Hannibal (known as a serial hugger only to the audience) form a brilliant partnership and it seems there's no villain they can't catch. If Will only knew.