Joan gets a lesson in popularity when God tells her to try out for the cheerleading squad, and her efforts to impress two pom-pom girls pay off with an invite to hang out together outside of school. Meanwhile, Will's first case working with Det. Toni Williams involves an abandoned newborn left in a trash bin, presumably by a student from Arcadia High. Another story line has a classmate sensing a gay vibe in Luke.
A drama about a typical family, the Girardis, facing atypical situations - not the least of which is their teenage daughter Joan's sudden, unexpected conversations with God in such random forms as a cute boy, Goth kid, little girl or the school lunch lady. Joan (Amber Tamblyn) must endeavour to balance the natural and supernatural elements of her life, often with little success. This is not the only major problem the family must face as her elder brother Kevin (Jason Ritter) was paralysed from the waist down in a car accident in 2002. As a result, her younger brother Luke (Michael Welch) often feels that his needs are being ignored.