Host Craig Ferguson is joined by guests Jimmy Kimmel, comedian Jen D'Angelo, and PR guru Howard Bragman as they debate and discuss history's biggest political blunder.

Host Craig Ferguson is joined by guests Chris Hardwick, comedian Jordan Carlos, and Scientist Bob Pflugfelder as they debate and discuss history's worst medical advice.

Host Craig Ferguson is joined by guests Courtney Cox, comedian Dan Soder and author/comedian Michael Ian Black as they debate and discuss history's biggest frenemies.

Guests Elijah Wood, comedian Bryan Callen and Professor Dan Schnur discuss history's most doomed presidential campaign.

Craig is joined by guests actress Julie Bowen, comedian Dan Levy, and professor Laila Lalami as they debate and discuss history's worst tyrant.

Craig is joined by guests Jack Black, comedian Tymberlee Hill and professor Stephen Prothero as they debate and discuss history's craziest cults.

Craig is joined by guests musician Trace Adkins, actress Kate Flannery, and entrepreneur Lori Greiner as they debate and discuss history's greatest invention since 1950.

Craig is joined by guests musician Lars Ulrich, comedian Tom Papa, and journalist Alan Light as they debate and discuss history's most influential band.

Craig is joined by guests actor Jack Black, comedian Tymberlee Hill, and professor Stephen Prothero as they debate and discuss history's most influential drug.

Craig is joined by guests Jay Leno, comedian Mark Forward, and PR guru Howard Bragman as they debate and discuss history's biggest fall from grace.

Craig is joined by guests actor Adam Goldberg, comedian Noel Wells, and Ty Pennington as they debate and discuss history's greatest man-made structure.

Craig is joined by guests Judd Apatow, comedian Kurt Braunohler, and astronaut Mike Massimino as they debate and discuss history's most plausible conspiracy theory.

Craig is joined by guests actress Angela Kinsey, comedian Heather Macdonald, and journalist Joel Stein as they debate and discuss history's biggest presidential bad boy.

Craig is joined by guests actor Tim Meadows, comedian Ian Abramson, and biologist Dan Riskin as they debate and discuss history's dumbest mistake.

Craig is joined by actor Jason Biggs, comedian Josh Wolf, and author and comedian Michael Ian Black as they debate and discuss history's biggest unsolved mysteries.

Actor Joel McHale, comic Thomas Dale and astronomer Derrick Pitts discuss and debate the greatest gangsters in history.

Journalist Larry King, comic Megan Amram and NASA astronaut Mike Massimino discuss and debate history's greatest unexplained phenomena.

Lisa Kudrow, Yvette Nicole Brown and John Avlon discuss the most defiant moments in history.

Actor Fred Willard, comic Jo Koy and journalist Joel Stein discuss and debate the best founding fathers in history.

Actor Michael Sheen, comic Russell Peters and journalist Joel Stein discuss and debate history's biggest frauds.

TV personality Regis Philbin, comic Mark Forward, former Secret Service Agent Evy Poumpouras