A woman from Mike's pastKelli Haddigan, who he has no memory ofhijacks "The Package", a taut man whose DNA holds a valuable cipher.
To stop a weapons smuggling operation, Mike infiltrates a drag racing gang with the assistance of a former Army buddy.
Michael and Zoe go undercover as a surfer couple to take down a terrorist cell in Baja.
Mike finds himself poisoned during an undercover operation, which leaves him with only three hours to live before his nervous system shuts down. To procure the antidote, Mike must fake the sleepytime of a billionaire tech mogul.
Mike must go undercover with a right wing militia group to figure out what their plan is and how a stolen triggering device fits into it. While there he finds help from a new friend. Meanwhile, Billy learns how to take care of himself.
The team must discover the identity of a cuddleer inside their own organization, when the body of a Tech is discovered. Mike and Sarah have their own concerns when they are stranded on a commercial flight and KITT's self-destruct program has been initiated.
Knight Industries tracks a criminal couple and discovers the felons have ties to the national congressional race. As things get hairier, Mike and KITT must step in to save Agent Rivai.
The team attempts to take down a money laundering operation in Las Vegas. Billy comes along on this mission and finds himself sidelined in his own operation. Dr. Graiman has his own problems when an ex lover comes to headquarters to assess how environmentally friendly the operation is.
A new virus spreads through out the world's computer threatening total annihilation, Mike is assigned the job to stop this virus from spreading. Only things become more problematic when KITT become a victim of the virus. Meanwhile, Sarah meets up with an old boyfriend and mike has a distinct reaction.
Mike is assigned to rescue a foreign Ambassador, who has been kidnapped. The kidnappers put them though several steps to secure the ambassador's release. Dr. Graiman and Sarah have their hands full caring for a sick robot.
Mike and KITT must drive faster than 100 mph to keep a bomb in the trunk from exploding; Sarah gets upsetting news about her father.
Sarah devastated by her father's passing decides that she needs to get away, only to be followed by a concerned Mike. While they are gone, the NSA shuts down the program and has KITT's main chip pulled. They decide to try again putting KITT's chip into KARR. When Mike and Sarah return, they, with the help of Zoe and Billy, are determined to fix KITT and put an end KARR.
Mike and KITT are assigned to find a serum that gives superhuman strength to anyone who uses it. Sarah is busy trying to resurrect the Foundation for Law and Government and is overwhelmed with this task.
When Jack Burber, a drill sergeant from Mike's past ishuged, Mike and one of his Army buddies begin to investigate. They discover that Jack was part of a fight club, which spurs Mike into joining the club to find out what happened.
Mike investigates a case of a plane crash and discovers that the crash was faked. The plane had been carrying a federal witness, a 10 year old boy who witnessed the hugging of his father. When Mike tries to help the DEA agent investigating the case, he ends up getting arrested. Mike realizes that it is up to him to find the missing witness before he ishuged. Meanwhile, Sarah tries to secure the future and independence of the SSC.
When Mike heads out of town for some R & R, he decides to look up an old friend, Sonny. When he arrives at the his bar, Mike notices that things have changed and is surprised to find out that Sonny died and his daughter, Julie is running things. Mike agrees to stay and help her put things back into shape, which becomes challenging when he discovers someone is trying to force her out.
Mike and KITT are assigned to find a serum that gives superhuman strength to anyone who uses it. Sarah is busy trying to resurrect the Foundation for Law and Government and is overwhelmed with this task.