Daimon Helstrom investigates a possessed young boy in Oregon. Meanwhile in San Francisco, Ana Helstrom stages an auction to expose a criminal. Disturbing events at St. Teresa's cause concern as the siblings estranged Mother remains hospitalized.

A horrific accident leads Daimon and Gabriella fighting to save a man's soul, while a darker force attempts to stop them. Meanwhile, Yen's relationship with his work takes a dark turn towards obsession, and a discovery leads Ana back to St. Teresa's.

Daimon and Ana learn more about the destruction their father left in his wake. With Gabriella, they pay a visit to a potential victim and find themselves in deeper than they ever could have imagined. Hastings shocks Caretaker with a stunning revelation.

A demonic enemy brings together an unusual group. Daimon and Ana travel to San Francisco in search of Yen and an artifact that may help defeat the enemy. Ana tells Daimon about her extracurricular activities, and Gabriella's faith is attacked.

Things are not what they seem as Mother's health sharply declines. As Ana searches for Yen, Gabriella offers counsel to a student struggling to understand how demons live among us. Daimon makes a discovery that is truly a matter of life and passing.

A dark force creates a melee forcing Hastings and Ana to work together. Daimon and Gabriella discover the events of the Blood Hotel are connected. The demon's identity is revealed, shaking Ana and Daimon to their core. Yen gets the upper hand.

With a powerful demon looking for a new host and Ana struggling to control her darker urges, Daimon is offered a proposition from The Blood. Caretaker finds himself in hot water, and Dr. Hastings rattles Daimon with new revelations about his past.

Relationships deepen as stakes increase. To save a life, Hastings and Ana must do the unthinkable. Gabriella and Daimon journey to his childhood home in search of an old relic. A mother loses a son but gains an heir.

Daimon and Gabriella find themselves in disturbing new territory. Ana has to make a decision that will change the course of the siblings' lives in irreversible ways. Victoria tries to make amends but she may be too late.

Ana and Daimon fight to save a soul but only Yen can be victorious. Gabriella's newfound perspective challenges Daimon's beliefs, creating riffs amongst the group. Victoria unites with Daimon and Ana, but their victory comes at a cost.