Luke and Lizzy have been inseparable since childhood. Now all grown up and in their 30s, they have decided to have a baby - in a non-traditional way. Lizzy, who is gay, is really ready to become a mom and who better to be the dad than her best friend Luke. Then, just as Lizzy discovers she is actually pregnant, Luke surprises her with the news that he has fallen in love and married Prudence, a free-spirited, British beauty who was due to go back to England in a matter of days. Suddenly, a different kind of family is born and the three must learn how to make it work together.

Lizzy is thrown for a loop when Prudence and all of her belongings move into the apartment she shares with Luke. Once there, Prudence pushes Lizzy to deal with some repressed emotions by cleaning out a closet filled with her ex-girlfriend's things. Meanwhile, Prudence's marionette puppets cause Luke some sleepless nights.

Things are looking up for Lizzy when she makes a date with her secret crush to go bowling and gets an appointment with the city's best ob-gyn. But then things turn complicated.

The ever-adventurous Prudence convinces Luke and Lizzy that they need to spice up their lives. Their idea of a good time is tackling the Farmers Market each week. Fearing that his new bride will find him too boring, Luke takes a chance at skydiving - with some disastrous results.

On a group trip to Las Vegas, Luke, Prudence and Lizzy visit the chapel where Nick and Prudence got married - only to discover that it was a sham and their marriage is not legal. Lizzy takes it upon herself to plan a spectacular new wedding with a special surprise. However, the group is in for an even bigger surprise about Prudence's past life in England.

After Luke learns about a secret that Prudence has been keeping from everyone, he disappears - leaving both their future and her immigration status in serious jeopardy. While Lizzy attempts to console Prudence and fix the situation, Luke hits the bars with Markus. And when all looks lost, Lizzy jumps in with a big, bold solution that will catch everyone by surprise.