Silicon Valley tech titan James Bell enlists Dr. Walter Wallace, an exceptional veteran surgeon with a controversial past, to run his state-of-the-art hospital with an ultramodern approach to medicine.

When a young boy's legs are crushed after being pinned by a car, Malik is determined to use a revolutionary procedure using spider silk to save his limbs, while Zoe lobbies in favor of the safer route of amputation. Also, James, Walter and Talaikha care for Amelia, a young woman in dire need of a liver transplant, but they're puzzled by her resistance when they tell her the donor is her estranged father, Simon.

When a police officer suffers a brain injury in a car crash and can't remember who he is, James suggests a cutting-edge method to re-code the man's brain to give him back the lost memories from his past and of his wife. Also, the team attempts to help an obese woman with the aid of an appetite suppression sensor, and Zoe tries to erase security footage of her kiss with Malik.

When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.

James convinces a hockey player with a severe spinal injury to undergo risky surgery that could enable him to walk again. Also, James invites Walter's wife, FDA executive Julianna Wallace, to Bunker Hill to persuade her to approve a new skin bio-printing trial,.

Walter and the Bunker Hill surgeons must perfect a revolutionary remote surgery when someone on the International Space Station needs an emergency procedure. Also, the team uses social media to locate the source of an E. coli outbreak in town; Scott's secret past is revealed; and Zoe and Malik's flirtation heats up.

The optimism of a young leukemia patient inspires James to become a better person; James confesses his feelings for Zoe; Julianna's Christmas visit with Walter reveals the strain of their long-distance marriage.

James and the Bunker Hill surgeons attempt to make medical history with the largest chain of internationally paired kidney donations ever, comprised of eight simultaneous organ transplants and 16 surgeries. Also, Zoe and Malik agree to go on a real date.

When a young man comes to Bunker Hill ravaged by a drug-resistant strain of HIV, James attempts a radical anti-viral treatment. Also, Walter must work quickly when his daughter's best friend contracts a fatal flesh-eating bacteria, and James makes a connection with Louis Keating's nurse,.

When a woman arrives at Bunker Hill with a mysterious lung ailment, James is conflicted after he connects other respiratory cases in her area to possible contamination from a microchip factory owned by his hero, tech guru Douglas Prescott. Also, Walter and Taliakha work to find why a young man can't walk despite his legs being in good condition, and Zoe becomes jealous of James's connection to Nina,.

James and Zoe work to help a teenage girl with a rare skin blistering disorder, employing radical treatments to heal her skin in time for her to attend her school prom. Also, as Louis Keating's GSS condition gets worse, James is tempted to use his experimental cure to save him. And Malik is jealous over the special connection between James and Zoe, while Zoe awkwardly meets James' new crush, Nina.

Talaikha and Malik treat Georgia Ray, one of the world's biggest pop stars and friend of James's, for laryngeal cancer, but when gold particles and microsurgery reveal more cancer than expected, they incur the singer's wrath when her vocal chords and career are threatened. Also, Angie's mother reluctantly sees Scott as a patient when she thinks she may be ill, and James is discouraged when he thinks Louis Keating's GSS is getting worse.

Angie tries to target her mother's illness using radical nanobot technology, but she looks to Scott for help when her mother prefers using traditional methods. Also, when a graffiti artist with a clotting disorder falls from a bridge, Walter, Malik and Zoe attempt to use suspended animation to stop his internal bleeding. And Walter is put in an awkward position when Julianna discovers James used the unapproved GSS drug on Louis Keating.