October 5, 1957 - November 22, 1963: As a result of leaping again before he had a chance to complete his original mission, Sam finds himself leaping back and forth through the life of Lee Harvey Oswald. Following the sole assassin theory, Sam and Al attempt to prevent Oswald's attack on John F. Kennedy. But, with each leap giving Oswald more control over Sam's body, history seems doomed to repeat itself.
Theorizing that one could time travel within his own lifetime, Dr. Sam Beckett stepped into the Quantum Leap accelerator and vanished... He woke to find himself trapped in the past, facing mirror images that were not his own and driven by an unknown force to change history for the better. His only guide on this journey is Al, an observer from his own time, who appears in the form of a hologram that only Sam can see and hear. And so Dr. Beckett finds himself leaping from life to life, striving to put right what once went wrong and hoping each time that his next leap will be the leap home.