After being the test subjects for a new pill, the guys find out that Peter is pregnant.

After going through a gender reassignment proceedure Ron and Peter become women for three days; Nugget tries to impress his father by letting him meet his new fiancee, Peter, his father then makes an indecent proposal; and Ron runs into one of his ex's after Kate introduces him to a group of lesbians.

After losing their memory testing new method of brain washing, Nugget convinces Ron and Peter that they are gay, so he can get revenge on the two for getting him a male stripper for his birthday party; Kate runs for the city's zoning commissioner, as a hard right wing conservative, so she can get a patio for her bar.

Ron and Peter get to test out a new military-grade vacuum. After getting it, it begins attack them for their messy lifestyles.

Ron and Peter test out a new super glue and a prank goes horribly wrong, resulting in Peter being superglued to Ron's backside, which Ron end's up using to his advantage, by taking Amy out on a date; Nugget opens up his own sperm bank in Kate's bar.

Ron and Peter test out an experimental pheromone spray that make women very attracted to them.

When Ron and Peter face their passings, they come to the realization that they haven't lived a full life.

Ron and Peter test out new chastity belts that emit an electrical charge when they get erections, after getting control of their erections and days left to go with the experiment they both meet women out of their league, so they must find a way to get the chastity belts off.

Ron takes care of Peter after he is paralyzed by testing out a new muscle relaxant; Nugget sets up an art gallery show, for a painting he found in the dumpster and then says a quadriplegic Peter painted them.

When the doctors at Testico tell Ron and Peter they've lost the ability to feel pain, they turn into daredevils.

Nugget moves into Ron and Peter's apartment, to live rent free, after they are blinded by a new shampoo.

Ron and Peter begin imagining symptoms after Testico will not tell them what they are testing out.

Ron and Peter test out a new truth serum for Testico, which unravels Peter's past and puts his friendship with Ron in jeopardy.