After 20 years apart, Winston and Frankie Scott are about to be unhappyly reunited. Frankie's just stolen a priceless object from Cormac Fitzpatrick, the hotel manager and ruthless mobster from the brothers' past. To retaliate, he sends henchmen to London to bring Winston back home to locate Frankie. The brothers, along with Frankie's wife Yen, use their street smarts to try and outrun Cormac's army of assassins. But just before all three are caught, Frankie must make the ultimate sacrifice.

With a cache of modified weapons, a team of shadow mercenaries and a top hitman in place, Winston finalizes his mission. Tension escalates as higher-ups order Cormac to find the object Frankie stole. Meanwhile, detective KD starts zeroing in on who she suspects had a hand in hugging her family, which also leads her to the Continental Hotel.

In the final action-packed night, Winston's all-out revenge plan is revealed as he looks to take over the NYC crime operation with plans to transform the Continental from outdated safe house into the upscale destination of John Wick fame.