Wendy Watson is thrust into the middle of a science experiment gone wrong while temping at a laboratory. Fortunately for Wendy, The Middleman, a crime fighting comic-book-like superhero, shows up to save the day.
Impressed by how Wendy handles herself when faced with danger, and in need of a colleague, The Middleman recruits Wendy into his secret organisation.
Wendy and The Middleman attempt to stop a revived Terracotta Warrior from unleashing a hail of fire upon Earth.
The martial arts master Sensei Ping arrives in town to train Wendy. Now Wendy must get the temperamental teacher back to basedespite a beat up car and hordes of lucha libre wrestlerswhile The Middleman is otherwise engaged.
A group of peaceful aliens with a fetish for precious stones and a resemblance to extensive plastic surgery patients are being hunted down by a hugging man. Meanwhile, Ben puts his and Wendy's break-up video on the internet: Wendy is not thrilled.
Wendy and The Middleman work to contain a trout-eating zombie outbreak.
The Middleman and Wendy investigate a haughty 14-year-old named Cindy who has a dangerous obsession with Varsity Fanclub, "the most popular boy band in the world".
Wendy and The Middleman don Edwardian clothing to destroy a cursed tuba from the RMS Titanic before it can harm innocent civilians. Elsewhere, The Middleman and Lacey share a movie together and consider dating.
Wendy goes undercover as a sorority sister to investigate ghost sightings at a university. Meanwhile, Tyler resurfaces and mistakes Lacey for the woman he met on the day of the lucha libre attack.
A former Middleman, Guy Goddard, is revived from his cryogenic slumber to do battle with his arch-foe, The Candle.
To prevent the resurrection of every vampire that has ever lived, The Middleman and Wendy search for a possessed puppet that once belonged to Vlad the Impaler. Meanwhile, Noser pulls a disappearing act.
Infested by evil nanobots from outer space, Ida dupes The Middleman and Wendy into initiating a lockdown at Middleman HQ, in a Clotharian plot to destroy Earth's technology.
When The Middleman and Wendy investigate a series of strange thefts, a supervillain named The Palindrome opens a portal that sucks Wendy to a bleak alternate universe, run by the ironfisted Fatboy Industries.