The Muppets find out ABC wants to film a documentary series about them, but Miss Piggy is not on board forcing Kermit to either get her on the show or break the bad news that the show won't air. Meanwhile, Fozzie has to meet his girlfriend Becky's parents who don't approve of her dating a bear. Imagine Dragons perform.
In an attempt to make Miss Piggy happy, Kermit sets her up with Josh Groban who fills her head with ideas on how to make Up Late with Miss Piggy better. Meanwhile, Fozzie is invited to a party at Jay Leno's house and everyone is annoyed that Bobo is selling cookies for his daughter's troop.
Fozzie takes things a little too far when Kermit offers him advice and Nick Offerman steps in to help the gang. Meanwhile, Christina Applegate guests on "Up Late", and brings Miss Piggy a sweet surprise that doesn't go over well and Pepe, Rizzo and Liam Hemsworth try to help Gonzo out with his online dating situation.
The gang has an epic night out when they run into Ed Helms at Rowlf's Tavern and they all perform their favorite karaoke jams, but Kermit is not pleased when no one shows up to work the next day. Meanwhile, Fozzie has an unfortunate accident during the show.
Miss Piggy and Reese Witherspoon have a heated rivalry but when the two volunteer for Habitat for Humanity, their feud escalates to a whole new level. Meanwhile, Fozzie and his girlfriend hit a rough patch.
Kermit is scrambling to find the perfect birthday gift for Denise, so he turns to Miss Piggy for help. Meanwhile, Kristin Chenoweth agrees to do a gig with The Electric Mayhem and inadvertently causes a rift between the band.
Kermit is feeling the pressure at work and is forced to go to a private Yoga retreat where he runs into a stressed out Jason Bateman. Meanwhile, with Kermit out of the office, Scooter is left to run the show and things go from bad to worse.
Scooter books his long time TV crush, Chelsea Handler, who really heats things up both on 'Up Late' and in Scooter's personal life. Meanwhile, Fozzie wants to take it to the next level with Becky but when Kermit and Denise go on a double date with them, Kermit discovers that Becky might have a few skeletons in her closet.
After a show-stopping duet with Miss Piggy on "Up Late with Miss Piggy", Joseph Gordon-Levitt joins Scooter, Pepe, and the gang for poker night. The Great Gonzo gears up to perform his dream stunt and Dave Grohl challenges Animal to a drum-off.
The gang prepares for a live Christmas special with Mindy Kaling; Miss Piggy gives Fozzy relationship advice; Yolanda rigs a gift exchange; Echosmith performs at the crew's holiday party.
The whole crew just returned from hiatus, and everyone is rested, recharged and ready to get back to work. But when a new branding guru comes in to revamp "Up Late", the gang rallies together and realizes that they don't need gimmicks and hijinks; they just need each other and a couple of familiar tunes to get them back on track.
When Miss Piggy suffers a scandalous wardrobe malfunction, the network is outraged, and Piggy is forced to question everything she stands for, but Kermit and the gang rally together and come to her defense. Meanwhile, Gonzo misses his ex-girlfriend Camilla, so Pepe and Rizzo decide to throw a house party to cheer him up.
Miss Piggy goes to an aerial silks class in at attempt to make new friends and Gonzo, Pepe and Rizzo fall under Pache's spell.
Sparks fly when Kermit and Miss Piggy pretend that they are back together for the sake of Kermit's impressionable nephew Robin. And now that Camilla is taking up all of Gonzo's time, Pepe and Rizzo audition for a replacement wingman.
When Miss Piggy breaks her leg rehearsing a dance number, Kermit gathers the crew and they broadcast "Up Late" from the hospital. Back at the studio, Rizzo, Pepe and Yolanda find creative ways to keep Pache occupied so he doesn't ruin the show while Kermit is out.
After her stint in the hospital, Miss Piggy and Kermit reevaluate their relationship, and Kermit turns to Jack White for advice.