International Rescue scrambles all the flight-capable Thunderbirds to rescue the crew of CIR.R.U.S, a high-atmosphere weather station, now in danger due to the arrival of a fierce storm. TB1, TB2 and TB3 are quickly crippled by the conditions, and the only hope of salvaging the mission lies with TB5 - and John's ability to mount his most daring rescue ever.
In the 21st century, Jeff Tracy, a former astronaut, amasses a colossal fortune and decides that he must use it to benefit others. His answer to this desire is to create International Rescue, a unique private emergency response service equipped with customized designed vehicles and equipment that enable the organization to react to any crisis whether it be in sea, air, land, or space.
Jeff's five sons volunteer to operate as the pilots and field agents, as well "Brain" who acts as the teams engineer. In addition, Jeff's friend, Kyrano and his daughter Tanusha aka Kayo agree to be the support staff. In addition to the field team, IR also maintains an intelligence network with Lady Penelope and her ex-con chauffeur, Parker as the chief agents in this arm.