The almost-broke and unemployed Lee finds out that Coreco Pharmaceuticals is looking to hire sales reps - female sales reps. He takes a chance and goes into the interview dressed in heels, a skirt and makeup. The transformed Lee gets hired - as a woman.

When newly-employed Lee and Angel go out into the field as sales reps for the first time dressed as women, former salesman Lee is confident he'll be successful while Angel is concerned his background as a mechanic will not serve him well.