MacGyver is reunited with Lisa, whose help cleared him of assassination charges in Switzerland, when a steel plant executive kidnaps her as revenge against her cold corporate-raider father.

A handicapped policewoman asks Fuller to send her undercover to investigate a series of attacks on handicapped women; however, Fuller also send in Hoffs in a wheelchair.

A series of outrageous practical jokes, which start with a visit from "Deep Throat", get out of hand.