The Charmed Ones are assigned their first case by Agent Murphy, going through cold case files and trying to solve them. Along the way, Billie discovers an enchanted belt that gives her superpowers, and turns the sexes against each other as a side effect. Elsewhere, a female demon wants to harness Billie's powers, and Paige hits it off with her new charge's parole officer Henry.

Marge buys a tandem bicycle, but Homer doesn't seem to be interested. Bart takes up the offer and him and Marge start to spend a lot more time together. All the while, Homer builds up a massive amount of stregth in one of his arms. Moe then enters him into the arm wrestling championships.

As the Smiths continue to live in Saudi Arabia, Stan is fully enjoying the male-dominated society, while the rest of the family struggles with the different social norms. Meanwhile, Francine's musical expos on gender roles gets her into trouble, and a brush with death leads the Smiths to return to the United States.

Lilly re-opens the 1999 case of a young, healthy woman who nevertheless died of a heart attack. In the late 1990s, she was briefly an Internet millionaire, but due to bad business decisions, her dot.com company eventually went bust.

Gabrielle tries to revisit her past when old friends come to town, but doesn't want anyone to know that she's three months pregnant when getting dressed up. With the aftermath of her breakup with Mike, Susan finds temporary solace from her ex-husband Karl as his relationship with Edie hits a bump. Also, the Scavo family learns more about the new neighbors, the Harpers when they babysit their children and uncover a sex tape of the couple. Lastly, Caleb gets loose from the basement and roams around Wisteria Lane at night, which leads to major consequences for Gabrielle.

After writing a story for a local magazine, Brian gets a job at The New Yorker. He admitted that he didn't graduate from college and lost his job. So he went back to college. In the end, he failed.

Meredith tries to avoid the Shepherds. Cristina and Burke go out on a date and end up getting caught up in their jobs. Derek asks Meredith not to ignore him until Addison comes walking around the corner. Derek and Addison take sides when a couple of their closest friends come in for a controversial surgery. Izzie helps Addison and Derek on their friends' case and when Alex tries to help by joking around their conversations take a more serious turn. A person falls five stories and becomes George's patient, much to the patient's dismay. Meredith patients won't stop talking about monogamy. Webber bugs Bailey about making a fellowship decision until he finds out that more is going into her decision than he knows about.

Lucius Vorenus is asked by Caesar to convince a veteran soldier to personally accept a large severance in exchange for agreeing to make the rest of the veterans calm down. Meanwhile, Titus Pullo murders a famous critic of Julius Caesar and he is sentenced to death in the arena when his lawyer fails to defend him properly. Octavian attempts to persuade Caesar to pardon Pullo for his crimes, though when his requests are ignored, Titus Pullo's fate seems inevitable.

Cheryl puts on a Passover Seder, which Larry promptly finds numerous ways to ruin.

When the trial of R&B star R. Kelly comes to town and Tom Dubois is the ADA, Huey and Riley are on opposing sides of the hot-button "underage peeing" issue. Elsewhere, during a checkers game, Granddad and Uncle Ruckus argue about white people.

Vicki Butler-Henderson takes on a death-defying challenge to get into the record books. Her goal is to drive in a straight line at 150mph - while wearing a blindfold. Tiff Needell takes the Ferrari F430 Spider for a spin at the Snetterton circuit, while Jon Bentley compares petrol brands to discover if premium fuels are worth the extra expense.

Coming Soon...