Stardate 48543.2: With the help of Cardassian scientists, the crew of Deep Space Nine begins the preparations for the deployment of a subspace relay in the Gamma Quadrant. Just moments before the scientists enter the station, a Vedek arrives on DS9 to warn Commander Sisko that a prophecy has foretold the grave ramifications should the project with the Cardassians continue. As Emissary to the Bajoran people, Sisko must decide whether to follow the orders of Starfleet or the will of the Prophets.

Stardate: 48546.2 With the reality of their situation setting in, Captain Janeway tries to think up some ways to better relate to a crew that finds itself a long way from home. Continuing their long journey to Federation space, the ship comes across a nebula where omicron particles have been detected. With the chance that they could be used as a fuel source, Janeway sends Voyager into the nebula to harvest them. However, the nebula turns out to be an organic life form, and is injured by Voyager's presence in its body. Facing attack, the crew desperately tries to break free from the entity's defensive systems in order to get out alive.

Mr. and Mrs. Smith? Will pops the question from his hospital room. And Lisa's answer is...

After learning Tracy's dying, Mitch intends to make their last moments together count but tragedy cuts short their time together. Logan and Caroline try to stop a pair of reckless wave runners from cauing harm on the beach.

There is a rat running amok at FYI as they move to their new ground level studio, with a "Window on America"; however, the animal rights activists react when Murphy is seen catching a rat on camera.