Hal learns that his father has passed away, but sheds no tears and passes it off as nothing since he never knew him. So, to make sure nothing like that happens again, he lets the boys do whatever they want by letting them miss school and even offering to buy Malcolm a new car, until Lois puts a stop to it. Noticing how depressed Hal has become, his friend Abe brings George Takei over for a visit in an attempt to cheer him up.

Paige begins to see the difficulties of dating a mortal, when Henry becomes too immersed in the magical realm. She is further conflicted when another suitor arrives, and wants them to form a magical power couple. Also, Piper runs into an old flame, and Billie finally finds her sister Christy.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase, but Karl is actually trying to get Susan to marry him instead so she can get insurance for her upcoming surgery. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. At the same time, Carlos learns more about the tension-filled relationship between Gabrielle and her mother when she drops by Wisteria Lane for a visit. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff. Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family (in fact maybe more than she may have wanted to know) through her parents.

Tina takes a business trip to Canada and has a chance to explore her feelings for the opposite sex. Dana's treatment puts a strain on her and Lara's relationship. Meanwhile, Jenny helps Moira in her transformation to Max, Carmen and Shane dedicate parts of their bodies to each other, Alice reverts back in her obsession over Dana, and Kit takes control. In a special appearance the B-52's perform at The Planet.

Granddad sends Riley to an art teacher after concluding his obsession with graffiti has gone far enough. Huey decides to watch black TV for two weeks after hearing that a woman died from watching too much black TV.

A minor drug dealer and flasher dies while in police custody and Sam suspects a cover-up within the unit. He demands a full investigation, though it seems none of the other officers is prepared to help. To Gene's relief, the pathologist's report appears to put everyone in the clear, but when the truth about the criminal's demise emerges, it's up to the modern-day cop to decide what action is appropriate.