Sarah is out of options, on the run, and pursued by deadly adversaries. Desperate to find her daughter Kira, Sarah suspects ruthless pro-clone Rachel is behind her daughter's disappearance and sparks an all out war against her. Alison and Donnie attend the funeral of her fallen friend, Aynsley, causing Alison to sink into guilt and despair. Cosima is faced with a perplexing decision that may have dire consequences.

Leonardo makes an unexpected discovery in the New World. Lorenzo attempts to save Florence with the help of an old flame. Clarice struggles to retain control of the Medici Bank.

Plans to build a new police station sees Endeavour and Fred questioning their respective places on the force. A boy disappears from a broken home. A body of a journalist is discovered on a railway line in strange circumstances.