Stardate 42073.1 After the Enterprise's new medical doctor is brought aboard, the vessel and her crew head to the Rachellis Star System to retrieve collected samples of an unknown plasma plague that has broken out there. The Enterprise must deliver them to a science station in order for a cure to be found. As they begin their journey to the star system, a mysterious beacon of light enters the ship.

MacGyver returns to his home town of Mission City, Minnesota to meet up with two old friends, Chuck and Neil, so they can dig up a time capsule they buried twenty-five years before. However, MacGyver is hesitant to dig the capsule up because he is still haunted by the death of his old friend Jesse, who died when MacGyver was young. But now MacGyver has another problem to deal with. Chuck's and Neil's sons, Danny and Sean, have gotten wrapped up in a drug deal, and the dealer is after Danny. Danny takes off to hide, and now MacGyver must find him, before the drug dealer does.

Kate goes back to work when a strike sends Willie home.

Miles assigns Corky to work with Murphy on a big story about a corporate big shot. Corky inadvertently uncovers the fact that he is a drug smuggler, this isn't immediately apparent to her. Murphy almost feels guilty about taking credit for the story, but she doesn't get the chance, Corky "grabs the brass ring".