Riza gets a call from Roy, but is unable to say anything in fear of being watched by Pride. In the town of Baschool, Ed and Al, along with Winry, lose the guards that were assigned to them and end up running into May and Marcoh. Meanwhile, Scar encounters a couple of Kimblee's men, a pair of chimeras, and runs into trouble with them. Scar gets pinned, but Ed and Al arrive and beat the chimeras, before restraining Scar themselves. Winry and Miles arrive, and Winry confronts Scar face-to-face about her parents' deaths. Explosions then take place and it appears that Scar has taken Winry hostage. Meanwhile, as Olivier's squad retrieve the survivors from the tunnels, Briggs is approached by some people.

It's Christmas party fever in the Emergency Department (ED) on Boxing Day as Noel heads to the celebrations at his father, David's, old people's home, and there's also the Dean's annual bash for the staff to look forward to. After a tough night in the ED, Zoe offers Noel a lift to his father's party. Noel is devastated when he doesn't recognise him but seems very close to another visitor, Jimmy. He's further worried by the fact that his father and several other residents seem ill. He begs Zoe to help his father. The F2s are on their way to help Noel's Charity Christmas visit but are suddenly called into action when they come across a car crash. Working together, they manage to stabilise their patients and get them to the ED. They are hailed as heroes by Adam in front of their colleagues and superiors at the Dean's Christmas party later that evening. The Dean, Eddie, proudly boasts to Henry that May is his daughter but she then tells him that she wants to make it on her own. Henry blurts the news to the other F2s and Lenny is disgusted at her lies and Yuki disappointed at her cover-up. Meanwhile, as Adam and Jessica's wedding day approaches, Adam completely loses his cool with a member of staff as the pressure builds at work and home. Ruth and Jay are thrown together to work on a medical case and Ruth finally admits that she's lonely after another family disaster. Letting down her guard, she accepts Jay's comfort and the pair head home together.

The three amigos attempt to travel from the Amazon basin in Bolivia to the coast of Chile in three locally bought 4x4s. "Locally bought" being a euphemism for rubbish. As well as the effects of altitude on their bodies, they must endure the local insect population and a run along El Camino de le Muerte - the 'Death Road'.