The Crone that previously targeted Piper's baby returns, this time stealing the senses of the Charmed Ones using a cursed statue. Piper goes blind, Phoebe goes deaf, and Paige becomes mute. When the Crone takes Leo prisoner, the sisters must tap into their magical sixth sense to save him and young Wyatt.

It's Christmastime and the family is out caroling. When they carol outside of a lawyer's house, he informs them they can't sing the song they're singing without paying a royalty. This inspires Homer to decide to write his own Christmas carol, but when Flanders tries to help and begins annoying him, Homer is instead inspired to write an anti-Flanders song. Homer plays his new song at Moe's where a passing David Byrne overhears it and offers to produce and record it. The song "Everybody Hates Ned Flanders" becomes a national hit and is even covered by William Shatner. To get away from the over-exposure of the hit song, the family decides to take a vacation to a dude ranch. At the Lazy I ranch, Comic Book Guy looks for an Internet connection and Lisa is annoyed to find out that the ranch was built on cruelty to animals and oppression of indigenous people. Lisa wants to go home, until sometime later when she meets Luke Stetson, a junior wrangler who shares her views. Homer and Bart meet some indigenous people who tell them that they've lost their land to a natural beaver dam. Homer gets them to agree to build a fair casino, if he helps them get back their land. Lisa overhears that Luke already has a girlfriend named Clara and her heart is broken. Lisa encounters Clara and gives her false directions to the dance. Homer and Bart manage to outsmart the beavers and indigenous people are able to reclaim their land. At the dance, Lisa finds out that Clara, her competition is actually Luke's sister. Lisa gets Bart to help her find Clara, who they rescue with the help of some beavers. The family is set to return to Springfield, when they hear a new David Byrne produced song on the radio "The Moe Szyslak Connection" and decide they can afford another week at the ranch.

Hank and the guys refuse to drink beer with Bill after he passes lice on to each of them. When Hank and the gang decide to shave their heads to get rid of the lice, Hank uncovers an unexpected "Bill" tattoo, and becomes irate. Meanwhile, Bill gets arrested and his popularity in jail pushes him into never wanting out, so Hank decides to go in after him.

A Rambaldi artifact predicts an event will soon take place. Vaughn and Dr. Barnett begin to worry about Dixon after the death of his wife. Also, Sloane recieves information from a monk in Nepal, that changes his life.

The detectives try to figure out a mystery after an old woman dies in a fire. The mystery gets deeper when a young woman who is left some of the old woman estate is killed. The case takes them to a state public administrator who has invented a form of grave-robbing. The detective suspects the administrator has a weakness for valuable cars, but to make his case work, he has to exploit his quarry's personal relationships.

When Fisher & Diaz undertake the funeral of a suicide victim, both Federico and Nate find themselves personally affected. The deceased, Melinda Bloch, killed herself shortly after her boyfriend, Alex Gramm, ended their long-term relationship. When Federico learns that Melinda had been under treatment for chronic depression, he peppers the emotionally shattered Gramm with questions about her illness. Federico can't help worrying that Vanessa - who has been taking antidepressants yet showing no improvement - could end up like Melinda Bloch.
Gramm then relates that he tried several times to end the relationship. "I stayed for years after I wanted to leave", he says, and for Nate his words resonate. He and Lisa have been having weighty discussions about their marriage and, after one particularly agonizing go-round, Lisa asks Nate whether he wants to split up. "Maybe", he tells her, "Yeah. I don't know. Maybe".
At the art show, Claire finds Billy Chenowith talking with Olivier. "He was my best student", Olivier informs Claire. When Olivier dashes off to work the room, Billy tells Claire that while he was Olivier's student he was also sleeping with him. "I had a lot of static around my sexuality", Billy explains, "and it was totally suffocating my work". Later, when Claire discovers that Olivier bought the sculpture that Russell exhibited, she once again wonders whether there's static around her boyfriend's sexuality.
The third party in the relationship is an ongoing concern with David and Keith as well. Following their night with Sarge, Keith would like to invite other men into their bed. During a therapy session, David - to Keith's chagrin - asks Frank, their therapist, whether he thinks three-way sex with strangers is a "healthy couple activity". Frank replies that it's all right as long as both parties are comfortable with it, and David says that he is. But when he and Keith go to a bar to seek their next bedfellow, it's clear that David is not as open to the idea as he claims.
Ruth and Arthur appear to be growing closer. Arthur gladly accepts her invitation to Claire's show and afterward they go to Ruth's room, where they sit on her bed and share some wine. Arthur starts to playfully rock back and forth, bumping into Ruth until he knocks her into a lying position on the bed. Ruth is delighted when he lies down beside her and asks, "Might I remove my glasses- But then, after some pleasant spooning, Arthur abruptly sits up. "I really should be getting back", he says, leaving a bewildered Ruth to finish her wine alone.
Nate and Lisa attend the art show and are having a horrible time. They've resumed sniping at each other and they run into by Brenda, who immediately recognizes Lisa from the spa. In the ladies room, Lisa confesses to Brenda that she was desperate to find out anything she could about Nate's prior relationship. Brenda tells her that she needn't worry. "I think you'll have him forever", she says, "if you want him". Later, as Nate and Lisa sit inside a sculpture of a plastic pyramid, they decide to start their relationship over again. They will be friends and lovers, without the pressure of pretending to be something they're not. "But what if it's never good- Lisa asks.
Nate replies, "Then we'll know we really tried".

Ricky wins the new position of Temporary Relief Assistant Trailer Park Supervisor as Randy is suspended. He then must choose his friend or his new boss

Segment #1 Jason "Wee Man" Acuna and Jack Osbourne are stopped by the MTV security and are denied access through the metal detector



Segment #2 Pink thinks she is being framed by her boyfriend for running a motorcycle "chop shop".



Segment #3 Stephen Dorff is set up to get stuck with an $8,000 var tab.