Rose plans a surprise birthday part for Michael. Tommy decides to play dirty to be the majority leader.

Walt Deekins (Ed Begley Jr.) decides giving is the road to happiness, and promptly writes a check to Laura to help her rebuild the school of course with some strings attached. Walt's wife Martha is not excited over the prospect and takes him to court saying he's not of sound mind because of the moons. Alex still has feelings for Claire, but humiliates himself while trying to help her solve a problem for work, and possibly loses her as a friend. Sarah Louise's son, Jonah, runs away from a "scared straight" school, and he and Lydia become friends although his motives are questionable.

The current Head of Household (Erika) must nominate two houseguests to go up on the chopping block for eviction; another food competition takes place.

Through an online video, Devon reveals to the world that she is going to start injecting herself with Promicin and that it will be available to the public soon. However, her body later rejects the Promicin, and Shawn is captured by NTAC while he tries to heal her. He refuses to tell where the Promicin is being held, but Isabelle manages to get the information from him. Predicting that she would find the location, Collier takes the Promicin from the warehouse and plants a bomb. However, Isabelle survives and decides that the only way to draw out Collier is to attack the 4400 Center.

In the third, and last, season finale, the camp turns out to vote-but as Bullock notes, the election may already have been decided. In light of the populace's mood, Langrishe delays the opening of his theater, and ponders his future in Deadwood. After detouring at Nuttall's Number ten, Hawkeye arrives at the Gem with "almost 18" men to complement Wu's contingent. Alma works out a deal for her claim; Utter recieves another body for Hearst; and Harry gets his fire engine. Stubbs reaches out to a frustrated Tolliver, who finds himself with a folded hand as the action heats up. Through Farnum, Hearst issues his conditions for departure, forcing Swearengen to finish what Burns can't.

Skip and Dee are dealing with a rape case between two college students. Skip's client Susan Palavi claimed that her former boyfriend Jared raped her at a party after they broke up, while Jared claims differently. Although, the case gets even more complicated when another raped victim comes out in the open to expose Jared's past deeds.

Johnny tries to thwart the assassination of the Vice President and protect the man that Janus' secret conspiracy has set up to take the blame, but it soon becomes clear that Janus has his own plans to assure Stillson's ascension to the White House.

With the apparent loss of the Ramones project and with Ari to blame, Vince and the guys begin to look for other agents to represent him. Ari, hearing of Vince's shopping, fights with all his might to get back the movie. While looking at other agents, Vince realizes they are just too corporate for him and the "scumbag" Ari is the best in the business. However, since Ari cannot get the movie back, he tries to win Vince back with a corporate-style presentation himself. This backfires because the boys find Ari to be just like everyone else now and fire Ari as they walk out of his office.

This week Carlos takes classic fairy tales and adds his very own Mencia twist to them. Conversation about sex, politics, and immigration are the topics of this Dinner for 75 and Over.

When a deadly virus is stolen from a laboratory, the team has less than 24 hours to stop a terrorist from letting it loose on the general public. Meanwhile, Angela's brother Jerry shows up with new evidence that their parents were imprisoned unjustly.

Louie worries about his marriage when Kim tells him that she hates him and needs some time away from him. Meanwhile, Walter wants to do his Bill Cosby impression but Ellen won't let him.

The deputies continue investigating the murder of Sheriff Chechekevitch at his funeral.