After entering an eating contest, Homer fills in for his truck driver opponent, who after the contest is no longer able to drive. While on the road Homer and Bart discover the other truckers' shocking secret. Meanwhile, Marge and Lisa's attempts to buy a doorbell introduce them to the heroic Seor Ding-Dong.

A mysterious dog thought to be the last of a rare Asian breed is responsible for several murders which Mulder and Scully are investigating. Now the agents have to find a way to stop the dog before it kills again.

Tony has become severely depressed since Pussy has mysteriously disappeared. Dr. Melfi has increased his Prozac dosage and placed him on Lithium and he begins to think about a beautiful Italian woman named Isabella. Junior finally makes his move and Tony is attacked while stopping to buy some juice at a newsstand. After the attack fails, Junior and Livia await their fate as an FBI agent tries to get Tony to say he was the target of a hit so he and his family can go into the Witness Protection Program and give up the rest of the New Jersey mob.

Due to an unforeseen incident, pizza delivery boy Philip J. Fry becomes frozen in a cryogenics lab. When he awakes 1000 years later, he's more than happy to have left behind his dismal past. He meets with an alien, Leela, to receive his permanent career assignment as a delivery boy. Fry refuses to perform the same job that had dissatisfied him in his old life, so he runs away. With the help of a robot friend, Bender, he attempts to permanently escape from Leela and her reminder of the loser he once was.