As Annie plans a mysterious day of cleaning as Eric discovers the shocking news that Mary ran away from "The Colonel"'s to come back home because of a devious scheme she had with Robbie and freaks out. Eric is convinced that more trouble is brewing and goes to insane lengths to find answers. In reality, Mary is heading home for a huge surprise birthday party for Eric, attended by all the people whose lives he's changed for the better in the past few years. Chores at home are interrupted, however, when Ruthie discovers Frankie and Johnny's baby, Mercy at the Camden front doorstep. Meanwhile, Lucy stays with her friend Mike's (guest-star Jeremy Lelliot) near catatonic mother for the day, and drops a proverbial bomb on Lucy. Also, Matt and Simon try to figure out why they delivered Mrs. Bink (guest-star Eileen Brennan) to the hospital.

Sheriff Valenti is suspended from the force after refusing to answer the FBI's questions about Max and Isabel, but he soon finds himself right back in the thick of things when Laurie DuPree shows up at his house claiming to be chased by aliens.

Andromeda encounters her damaged sister ship, the Pax Magellanic, floating in space where a planet should be. Her crew haven't aged since the fall of the Commonwealth, and her computer seems to have gone mad...

John has his hands full when a former patient dies and leaves him his ashes, and a current patient suffers a puzzling rapid heartbeat. Elsewhere, Reggie turns a blind eye to her handsome new boyfriend's glaring flaws.

Jenna is marching around the Training Center with Phil Price, a photographer getting publicity shots of her in action. Meanwhile, Zack is showing around Peggy, one of the trainees. They get a frantic call: a scuba tour group has lost some of its members near a reef. Seeing an opportunity for some photos in action, Jenna grabs Phil and directs Sean to bring him with them so he can get the shots. Zack will ride shotgun with Jenna. As they near the area the call came from, Sean notices that the channel marker is missing. He warns Jenna and Zack, but they are too intent on the rescue. The jet ski hits a reef and flips, tossing Jenna and Zack into the water. Zack breaks his ear drum, but suffers through the pain in order to get Jenna, who is trapped under the water. He and Sean rescue her.

Doug sets up his sister with Carrie's boss so that he can watch the Super Bowl on a high-definition TV.

Tonight, actor David Boreanaz promotes his new movie Valentine.

Mike's day gets off to a bad start when a politician dies during a routine operation - and when a newspaper reporter gets hold of the story, things go from bad to worse. Alex solves a riddle with welcome consequences for a new mother.

Daniel tells Betty that he intends to liquidate Ecomoda, which makes Betty and the barracks look for Armando, who is in the production area saying goodbye to the staff.