David ignores protocol and hires his new lover, Enuka; Mayko is contacted by the parents of a sick child who believe she's the only one that can help.

Lisa makes a documentary of her own family for a school project, and the film is so impressive that Superintendent Chalmers and Principal Skinner push her to enter the documentary in the Sundance Film Festival.

Bobby has to work as a deputy for the school's police officer after he is framed for throwing a soda can. Meanwhile, Hank accidentally takes the wallet of a man he thought stole his own wallet, however when he tries to return the wallet the man does not take it too well.

When the PTA protests about smutty books at school, Justin and Franny are forced to read the books for the first time. Claire uses the protest as an excuse to getting out of reading "Pride and Prejudice". Justin turns to Raja when his parents find out that he has been drawing pictures of naked women.

Kris insists the family take a vacation in Colorado in hopes of putting an end to some bickering, but the trip doesn't go exactly as planned.

Roger begins to release photos of himself to the local media for extra cash, prompting the CIA to initiate an Alien Task Force. Through a twist of fate, Roger ends up in charge of the task force in disguise, creating tension at home as he is now Stan's boss. Meanwhile, Francine comes to grips with being left-handed and Roger frames Stan as an alien in attempt to keep his identity a secret.

In the season finale, a drug addict mother, who lost her son in an apartment fire in 2005, comes forth claiming she just saw the same child in the park.

Susan meets her ex-husband, Karl (guest star Richard Burgi) at a Lamaze class, and finds out that he has remarried and is having another child. Lynette learns who was responsible for starting the fire at Rick's restaurant. Bree wants Orson to turn himself in to the police. Gabrielle rents a room to a hip artist, Ellie (guest star Justine Bateman), who has a dark secret. Dylan continues meeting with her father, Wayne (guest star Gary Cole), and Katherine decides to go spy on her.

When Peter gets a pet parrot, he begins acting like a pirate. Peter accidentally kills the bird after raising hell through all of Quahog. Meanwhile, when Brian is visiting the vet, Chris falls in love with the intern, Anna.

Thanksgiving arrives; winter weather strikes and the men of Pihl lose one man after another to illness. The younger crew members of Gustafson blow off steam while the bosses toil away. Jay is forced to ax some of the Browning gang staff. The season's first snow is a warning of things to come for the Stump Branch crew.

After an international business deal goes bad, Holly becomes the saving grace for Ojai Foods. Meanwhile Justin delivers heartbreaking news about a family member, and Saul makes a shocking confession about himself. Also Scotty and Kevin share a life-changing moment together.

Despite the Pope excommunicating Henry, the Reformation continues. Sir Thomas Cromwell is tasked to make the king and the Reformation more popular and he uses plays to achieve this goal. Henry has nightmares featuring Thomas More and Anne Boleyn becomes increasingly insecure as Henry continues to have affairs.

Moz reminisces about 1993, the year he first moved into the flat.