Stardate: 41209.2 When the Enterprise is ordered to investigate what has happened to the Starship Tsiolkovsky, they find everyone dead due to bizarre incidents. Later they realize that the away team has brought back the contaminant that killed the Tsiolkovsky crew, which is past on by skin contact. Although similar to the effects that affected the past 1701 Enterprise crew, that cure isn't affective in this case. This Enterprise faces the same fate as that faced by the 1701 Enterprise, unless they too can find the cure to the contaminant.

To make matters worse, the star the Tsiolkovsky was studying is about to go super nova, and Wesley Crusher, affected by the contaminant, disables the ships engines, leaving the ship in the path of destruction.

The Beagle Boys steal Gyro's handheld teleporter and use it to steal Scrooge's fortune.

Jimmy Kendall, living undercover after testifying against his Mob bosses, surfaces when he becomes the manager for a winning baseball team.

Mrs. Ochmonek thinks she's gone crazy when she spots ALF in the backyard.