Mimi is the new owner of Nolita and a power-struggle with Jack enfolds. The two fight for control over the restaurant and staff but when a surprise health inspector shows up for an inspection, this prompts Jack to try and bribe her and Mimi doing the inspection the honest way. Also, Jim deals with Tanya's kiss, and trying to keep it secret from Seth who has a history of crazy jealousy.

An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a "Code Black" for the hospital. Bailey worries where her husband is as she is in labor. Also Izzie and Alex may be creating some heat.

As Tina finds herself attracted to men, Bette explores Buddhism and also hears good news on the work front. Both Alice and Kit try out speed-dating; Kit with Angelica's male nanny Angus and Alice with a lesbian vampire. Meanwhile, Dana receives devastating news about her illness, Helena pursues documentarist Dylan Moreland, Moira goes out as Max, and Shane's ex drops by to see her.

When a Manchester United football fan is murdered, police suspect a rival City fan's to blame. The incident raises fears of a riot between supporters of the two teams, whose derby match is taking place at the weekend. Sam, Gene and WPC Annie Cartwright go undercover to gather evidence. But Sam worries they'll fail to find the killer before Saturday's big match. Meanwhile, Sam's relationship with the young son of the murdered man brings memories of his own father flooding back.