A hormonally charged Sue wants a cool pair of jeans in order to fit in with her peers, resulting in Frankie and Mike enduring the unpredictability of teenagers, while Axl wants a car to impress a girl. Meanwhile, attempting to teach Brick about responsibility, Frankie and Mike reluctantly allow him to take care of Aunt Edie and Aunt Ginny's dog Doris for a few days.

Veronica helps a patient after a terrifying experience on an operating table. Meanwhile, Veronica begins to think that Mike has begun dating again. Sonio tries to find a patient's next of kin, but instead comes across a secret that will change the young girl's life forever. Elsewhere, Chloe is forced to moderate a family feud when a family can't agree on the course of action for their dying father.

When Sue has a run-in with her sons, Frankie fears that a confrontation with the trasy neighbor may be at hand. Meanwhile, Axl attempts to bribe Brick after he's asked to teach his little brother how to kick a ball for a gym requirement. However, Brick is the one turning the tables and it ends up bribing him for another favor.

Coach Taylor begins to realize most of the team's problems are off the field rather than on it. Meanwhile, Jess is forced to choose between Vince and Landry, Luke struggles to deal with his injury, and Riggins makes a decision that may not work out as well as he had hoped.

One case becomes two as a murder leads to a serial rapist who is busy spreading disease along with his assaults, and the detectives' only clue is a website set up for casual and anonymous encounters.

While on a Panamanian island, Bear Grylls must create fresh water and fish for food.

When Javier, Manny's unreliable dad, arrives, Jay's reaction is less than enthusiastic, worrying Gloria. Meanwhile, Claire is left with no other choice than to call for the hot firemen to rush Phil to the hospital when he suffers from kidney stones. Also, Mitchell and Cameron attempt to sleep train Lily, but they have a harder time than she does.

The Doyles help a close family friend beat a manslaughter charge despite the fact that he refuses to defend himself; Jake's relationship with his ex-wife, Nikki, is heating up when it should be cooling down - and Leslie might be the perfect distraction.

Despite their fear of the meanest dermatologist in town, Dr. Amy Evans, Jules and Ellia are willing to endure the wrath for an appointment with the best in the business. However, after Jules learns that Dr. Evans is seeing Bobby, she's determined to protect him from her. Meanwhile, Travis' new job, which is working for Barb, turns out being more than what he bargained for.

When Sean and Christian win an award from their alma mater, Sean recalls their college years; a new patient who self-mutilates comes to McNamara/Troy for reconstructive surgery.

Concerned that she may be spending too much time with Matt, Betty tries to give him something else to be passionate about, which turns out to be a surprise gallery showing of his art work. However, the exhibit as some unintended results. Meanwhile, Marc is horrified when he uncovers that his one-night stand is falling for him, while Hilda must decide whether or not to tell Bobby that he's the father of her future child. Also, Cal Hartley hires a Hollywood powerhouse to replace Wilhemina.

The Jay Leno Show welcomes actor Hugh Jackman and news anchor Katie Couric.

When Ashley and Mike kiss, Andrew tries to stir up some romance of his own by seducing Callie. Meanwhile, Ty and Emily also begin to see something special between them as well.

Guest: Jack Schaffer

Tonight Stephen welcomes the founder of the Algalita Marine Research Foundation, Charles Moore.

Marv Albert and Julian Casablancas are the scheduled guests.

The Tonight Show with Conan O'Brien welcomes actor Matthew Broderick, actress Robin Tunney and musical guest Ke$ha. Also, new Celebrity Surveys!

After insurance investigator William Byfield is found dead, Harry's initial examination makes it look like it could of been suicide. After another examination, the team start to believe that he could have died from cyanide poisoning. Hos replacement, Clare Ambler begins to believe that his death could be linked to his investigation into the death of Stephen Connelly.