Number 45, "Ditched Jessie to Marry Joy" is next on the list when Jessie, Earl's ex-girlfriend, returns to town seeking revenge. Earl must protect Joy in a lakeside retreat while Randy fights not to reveal their location to Jessie.

Distraught over her break-up with Clark, Lana goes to a rogue medical student who experiments with a dangerous kryptonite-based serum that allows people to flat-line but see their dead loved ones. Lana attempts to see her dead parents using the serum and when Clark returns from Honduras to help her, the doctor injects him with the serum and Clark speaks with his dead father...who warns him that Lionel knows his secret. Meanwhile, Lionel continues working to get closer to Martha, and Lex has a near-death vision of his mother.

Two tribe members are sent to Exile Island and they form an unexpected bond. Castaways from the original La Mina team try to break up the Casaya alliance. At tribal council, the eighth person is voted off of the islands.

The team investigates the death of a psychic who "saw" her own death while performing a reading for two other women. Greg reveals a family secret to Grissom but Grissom believes that science will be what solves the case.

When the gang receives their college acceptance and rejection letters, everyone must decide which path they want to take. Sandy and Kirsten become concerned about the decision that Ryan and Sadie come to. The letters lead Marissa and Summer work on patching up their friendship while Taylor decides to throw a College Sweatshirt Party to celebrate the letters arriving. Meanwhile, the toll that Sandy's job is taking on him begins to strain the Cohen household.

When Sam and Dean find articles about a town where children are inexplicably falling into comas, the brothers discover that a Shtriga, a creature that attacks children, is behind the mysterious comas. During the battle, Dean remembers a past battle with the creature that almost resulted in Sam's death.

After losing his job as the host of 'JackTalk,' Jack vows never to return to acting. An unrelenting Karen, however, will not let Jack give up on his passion and decides to do whatever it takes to get Jack to an audition. Meanwhile, Grace accompanies Will to dinner at his parents' home, but a simple dinner soon turns into a showdown between Will and his father when his dad decides to give Grace's unborn child Will's cherished baby blanket.

Meryl seeks Sam's expertise to assist with a vital presentation she's giving to the Chinese Department of Transportation.

Season three of The Ultimate Fighter pits legendary rivals Ken Shamrock and Tito Ortiz against each other. As coaches, Tito and Ken train a new army of mixed martial artists from the U.S., Canada, and Great Britain. The fighters are evaluated, teams are selected, and two middleweights clash in the Octagon for a chance at becoming the next Ultimate Fighter.

TONIGHT: Actor and star of Lucky Number Slevin, Josh Hartnett! Also, Dan Bakkedahl learns about "Beach Ploys".

TONIGHT: Stephen Colbert welcomes the owner of TheDailyKos.com and the co-author of "Crashing the Gate: Netroots, Grassroots, and the Rise of People-Powered Politics", Markos Moulitsas!

After a completely false expos in a newspaper, one of Stacie's friends attempts suicide out of shame the article caused. To help right this wrong, the Hustle crew decide to take down the men responsible - the editor Frances Owen and reporter Tim Millen.

The con? To convince these two muck-rakers that they have the biggest Royal scoop ever and that they'll be making headlines. Of course if Mickey and the gang have their way, their headlines will be a little different than the way they intended.

Statham, when not drawing breasts upon his x-rays, is trying to make Joanna jealous with increasingly desperate pretend sexual exploits. Mac is back at work and, with no help from Guy, is causing Caroline grief as he can't remember the twenty minutes that they were an item. Meanwhile, Karen and Martin have moved on to the next level and she's wearing him out.