Via a new source, Mulder receives a tape of a 911 call made by a man in New York City who said that his Lexington Avenue apartment building was on fire. The apartment buidling, however, had not caught on fire, yet the man had died from internal injuries associated with being burned in a fire. Mulder tries to open a case file on it, but is beaten to the punch by another agent, and his new partner, Alex Krychek.

Pedro's health weakens and he is sent to the emergency room with a temperature of 104 degrees. The cast begins to realize the full extent of his sickness and tries not to let it bother them that he is getting closer and closer to the end of his life. A confused Mohammed breaks up with Stephanie, hooks up with a friend from San Diego, then calls Stephanie crying and tries to repair what is left of their relationship. To take a break from all of the drama in their lives, the group goes horseback riding.

Two homeless girls are drawn into a murky underworld. A woman who thinks she has the answers to her husband's collapse discovers that life is never that simple. Ash is put on the spot when Mike Barratt takes him into his confidence.