In the premiere of this series it introduces Eric Camden (Stephen Collins) who's a minister and father of five children and is happily married and soon-to-be dog owner. His wife, Annie Camden (Catherine Hicks) is a stay-at-home mom raising their children. Matt Camden (Barry Watson) is the oldest child who has picked up a habit of smoking and not being able to keep a job. Mary Camden (Jessica Biel) is the oldest daughter who likes to play basketball a lot and is having a craving for wanting to kiss a boy.
Lucy Camden (Beverley Mitchell) is the middle child and is hoping to become a woman and getting her period very soon. Simon Camden (David Gallagher) is the youngest son and is hoping to get a dog very soon, even though his parents already told him that he's too young. Ruthie Camden (Mackenzie Rosman) is the youngest child and is a happy and adorable 5 year-old. Also, Annie learns some devastating news when her parents come for a visit as her mother has leukemia.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.