Eric flies to New York in a last attempt to convince Chandler's dying father (guest star Dan Lauria) to make peace with Chandler before it's too late. Meanwhile, Matt (guest star Barry Watson) and Sarah (guest star Sarah Danielle Madison) suspect that she might be pregnant and Matt's co-worker lets the news slip to Eric; Lucy fears she might also be pregnant, which causes her to panic and push Kevin away; Mary (guest star Jessica Biel) tries to find Eric to tell him that she did something stupid; Lucy offers her classmate Christine (guest star Tara Lipinski) a temporary place to live, unaware that she's hiding a big secret; Simon is crushed when Cecilia refuses to go to the prom with him; and no one can understand why Ruthie is acting especially strange.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.