Matt (guest-star Barry Watson) returns home to tell Eric and Annie that Sarah has left him and he's dropping out of medical school. Rabbi Glass offers Matt marital advice. Meanwhile, Kevin must decide whether or not to tell a very jealous Lucy that his ex-wife (guest star Mindy Burbano) is in town and they got invited to dinner with her. Martin's aunt (guest star Keri Lynn Pratt) asks Eric to step in and talk Martin into moving to New York with her and Chandler asks Peter how he would feel about Chandler marrying his mother someday. Peter thinks something is amiss when his mother goes out of town for a business trip. Ruthie keeps something from her mother.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.