The Camdens, especially Lucy and Ruthie, grow concerned that an unusually joyful Annie isn't dealing with her true emotions following the passing of her father Charles, but the happiness proves to be infectious as it soon spreads through the family and all over town. Meanwhile, Eric tries to convince an unhappy Chandler that he should consider adoption, which leads to a meeting with a lawyer (guest-star Randy Spelling). At the same time Chandler is approached by a mysterious young girl who gives him a cryptic message before she disappears.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.