Mary (guest-star Jessica Biel) makes a surprise visit home to deliver unexpected news to Eric and Annie. Meanwhile, Simon tells Cecilia (Ashlee Simpson) that he needs space. Also, Lucy and Kevin adjust to married life. Chandler breaks up with Roxanne after learning that she isn't comfortable with the idea of being a preacher's wife, while Roxanne seeks Kevin's advice on dealing with a dispirited Chandler. Also, the Camdens finally learn who's pregnant. Lastly, Eric ponders Simon's academic future and Annie prepares for a potentially tense dinner engagement.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.