With the Thanksgiving holiday just two weeks away, Eric and the kids notice that Annie is acting very strange, especially after she learns that Matt and Sarah (guest-star Sarah Danielle Madison) won't be able to spend the holidays in Glenoak. When Matt and Sarah decide to come by early and spend some time with the family before the holiday Annie is not pleased. In fact, the majority of the family has made plans of their own and Eric worries how Annie will take the news. Carlos (guest-star Carlos Ponce) telephones the Camden's and tells them that he, Mary and baby Charles are going to spend the holiday in Puerto Rico with Carlos' family and wants Ruthie to join them. Meanwhile, Simon has something to tell his parents, but can't get up the nerve to tell them - which involves his former girlfriend Georgia who shows up back in his life unexpectedly. Instead he decides to stay at school for work. Also, Martin has plans to go camping with Mac (guest-star Kyle Searles). Lastly, a strong-willed and pregnant Lucy is determined to do the cooking and decorating this year but forgets to tell Annie about her plans.
Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household. This year, Eric and Annie will find their family back together in Glenoak with the return of Matt and Simon.
As is often the case when the house is overflowing with Camdens, Eric and Annie are in for a bumpy ride as their children take landmark steps in their lives. Meanwhile, Eric and Annie continue their journey as soul mates, parents and grandparents whose love and respect for each other brings them ever closer.
Through all the ups and downs, Eric and Annie have managed to keep their romance alive and their family together. Not only are they raising their own seven children, they've picked up several additional family members along the way.