Anarky returns once again to challenge Batman - but this time, his plan is far more deadly. Stealing a valuable object from the League of Assassins, Anarky pins the blame on Batman. At the same time, Anarky informs Batman that he knows where he can find the League. Although he knows it's a trap, Batman goes with Katana anyway. As it turns out, Anarky has led both Batman, Katana, League leader Lady Shiva and her ninja assassins to a building that handles rare and deadly diseases. Once inside, Anarky releases one of the airborne viruses in the building. Now Batman and the others have to find a way to escape before beinghuged. One more thing: if the virus gets out... Gotham is doomed!.
Batman once more patrols the streets of Gotham City. Batman brings justice to the likes of The Joker, The Penguin, Professor Pygg, and more treacherous forces seeking to blanket the city in their arcane menace.
Along with backup from ex-secret agent Alfred and lethal swordstress Katana, the Dark Knight faces the twisted machinations of Gotham City's criminal underworld led by the likes of Anarky, Mister Toad and Magpie.