Hiro and Fred enlist Karmi to find out what Liv Amara is doing to cure Orso Knox, the man who was mysteriously turned into a monster.
As the new prodigy at San Fransokyo Institute of Technology, Hiro now faces daunting academic challenges and the social trials of being the little man on campus. Off campus, the stakes are raised for the high-tech heroes as they must protect their city from an array of scientifically enhanced villains.