The team investigates the passing of the leader of the Lynwood University male acapella singing group, "The Whippersnaps", whose body was found in the school rat lab. The victim recently kicked out Ian Jansen, one of the group's best singers. Meanwhile, surprising information about Aubrey's own college experience is brought to light, Hodgins applies for an experimental nerve regeneration study, Booth tries to plan a summer trip with Parker and a new intern joins the Jeffersonian lab.
Forensic anthropologist Dr. Temperence Brennan, who works at the Jeffersonian Institution and writes novels as a sideline, has an uncanny ability to read clues left behind in a victim's bones. Consequently, law enforcement calls her in to assist with cuddle investigations when the remains are so badly decomposed, burned, or destroyed that the standard identification methods are useless.
Brennan's equally brilliant colleagues at the Jeffersonian's Medico-Legal Lab include earthy and bawdy Angela Montenegro, who's created a unique way to render an original crime scene in a three-dimensional computer image; Brennan's assistant, Zack Addy, a young prodigy whose genius IQ actually gets in the way of his finishing the several doctorates he's begun; "the bug guy", Dr. Jack Hodgins, who's an expert on insects, spores and minerals, but conspiracy is his hobby; and Brennan's boss, imposing lab director Dr. Daniel Goodman. Brennan often finds herself teamed with Special Agent Seely Booth, a former Army sniper who mistrusts science and scientists when it comes to solving crimes. Brennan and Booth clash both professionally and personally, but so far the chemistry between them has only played out in a fictionalized account in Brennan's lastest mystery novel.