Despite battling his disease, Mayor Thomas Kane ensures his political future by announcing impressive enhancements to the terminals at O'Hare airport.

Needing to find a replacement for Stone, Kane hires an ambitious newcomer to the political scene and entices his adversary's aide.

Kane decides to redevelop a housing project, to get closer to Mona.

While his wife and daughter reject his efforts to reconnect, Kane streamlines his political staff.

While the symptoms of his disease leave him unable to differentiate between reality and hallucinations, his hold over the City Council is threatened by his anti-corruption stance.

With riots breaking out at the housing project, Kane seeks treatment at an alternative clinic, but his past comes back to haunt him.

Now that Kane's treatment seems to have worked, he must regain control of Chicago.

In order to keep his grip on Chicago, Kane finds he has no choice but to work with Alderman Ross.

As the city's emergency managers prepare to take over, Kane's enemies threaten to unseat him.

While Miller publishes a story that threatens to destroy Kane, he battles to stay on top, but is concerned over Doyle's alliance with Kitty.