A comedy following the antics of a pair of twentysomething best friends in New York City begins with Abbi and Ilana trying to scrounge up the money to buy tickets for a secret Lil Wayne concert.
The ladies' grown-up behavior includes Abbi buying marijuana and Ilana doing her taxes.
Ilana tries to make some extra money as a temp; Abbi promises her neighbor that she will wait for his package, but when she misses the delivery, she must go to the ends of the earth to recover it.
After Abbi bug bombs her apartment, and Ilana misplaces her keys, the girls are forced to face life on the streets and all this happens just in time for Abbi's first art gallery show.
Abbi decides she's too nice so she tries to be the opposite; Abbi and Ilana attend a high-end party and meet some adventurous DJs.
After trying to find men on Facebook, Abbi and Ilana decide to meet some guys in real life.
Abbi and Ilana ride out an upcoming storm with their number twos and number threes (Jaimé, Lincoln and Jeremy) but are unfortunately also joined by Bevers and his sister; game of Who Done It? plays out while the hurricane rages outside.
Lincoln and some old catering co-workers join the girls to go to a wedding but the trip becomes a comedy of errors abd Ilana must confront Abbi's past friendships.
Abbi is riding high after selling her art, but when Bevers pushes her to the breaking point, she starts the search for a new apartment; Ilana is trapped in her own personal hell as she deals with the cable company and a creepy ex.
The girls go to a fancy restaurant for Abbi's birthday; Abbi must come to terms with being nasty; Ilana pushes through self-inflicted side effects of their fancy meal.