A few years have passed and Hank is living in New York but looking for a ticket out of town after his latest breakup.
Hank passes on writing Samurai Apocalypse's new movie but Sam won't take no for an answer and drags Hank to a meeting with director Peter Berg, where they discover that Hank and Peter have shared more than just a love of the written word.
Hank delivers a completed draft of "Santa Monica Cop" to Samurai Apocalypse but his attempts to leave town are once again thwarted when he's asked to show a night on the town to Kali, his "acquaintance" from the flight to Los Angles; Tyler crashes with Karen and Becca while he recovers from his injuries.
Hank receives an unwelcome surprise in the form of Carrie, ex-girlfriend and arsonist that he's forced to invite along when Karen and Becca show up to invite him to a dinner party. Stu, Marcy and Bates' talk of sexual proclivities leaves the Moodys searching for the nearest exit, but the party gets even more out of control when Carrie has a realization about Hank.
Charlie's boyhood dream is realized and Hank's worst nightmare comes true when Samurai Apocalypse invites the boys on a ride-along with the Santa Monica Police Department and takes them on a joyride that goes sexually awry for Charlie; Richard hits the bottle at a crowded Venice restaurant but Hank and the boys arrive to save the day for Karen and Becca, and Tyler realizes he's seen Sam somewhere before.
When Samurai Apocalypse hits a lyrical roadblock with his protege, he calls on the best writer he knows: Hank Moody, who unites with Kali to imbibe, bear his soul, and write a song that takes Hank back in time to an era when he, Karen and Charlie were happier and life was simpler before "A Crazy Little Thing Called Love". But the present comes roaring back when Karen shows up at Hank's door, worried that she made a mistake.
Hank saves Karen from embarrassment with a drunk Richard, then covers for Richard by pretending to be dating a stripper named Holly, who takes a liking to Tyler and offends his girlfriend, Becca. Meanwhile, when she's fired after an inappropriate encounter with Stu, nanny Lizzie calls on Charlie and allows their relationship to progress, only to have Marcy beg for her return.
Hank is stuck reading Tyler's screenplay but discovers some talent under that head of hair, even though the script appears to be disturbingly autobiographical account of the author's relationship with Becca. Charlie and Lizzie's love quadrangle with Stu and Marcy heats up, but when their bedroom games hit too close to home for Charlie, it may be off to therapy for all four of them.
On the first day of production on Hank Moody's latest movie "Santa Monica Cop," Stu has brought back his "F-king and Punching" director in hopes of creating a cinematic masterpiece, but Hank's rendezvous with the film's leading lady puts his relationship with Sam in jeopardy. Luckily for Hank, Stu and the production's crew, Charlie has a backup plan.
Minus one agent and best friend, Hank crashes with his two favorite ladies, Karen and Becca. Looking for new representation, he meets with Hollywood power agent Larry Levine, who quickly sets a meeting with world-class filmmaker and Hank Moody idol Lars Manderhoff. It may be a match made in heaven when Lars surprises Hank with one of his favorite working girls, Trixie. Distraught over his personal losses, Charlie seeks comfort from Marcy while Lizzie enjoys her big break, a part in "Santa Monica Cop" courtesy of Stu.
Hank overstays his welcome at the house of Karen and Richard and hits the road with one last stop at Malibar, where he runs into Lizzie, who uses her newly acquired acting chops to lure him back to the Runkle Manor. Once there, Hank is surprised by everyone he loves and loathes: Karen, Becca, Charlie, Marcy, Stu, Richard and his creepy sponsor, Gabriel. Even Sam and Kali show up, but it's not a party until someone gets hurt and luckily for these partygoers, Hank has it in him for one final run-in with Tyler.
Hank discovers the bartender at a local watering hole is his late friend Lew Ashby and wonders if he's in Hell. Richard makes a startling announcement about Hank and Karen. Hank tries to make things right with Becca, but her news about Tyler leaves him stunned. On the set of "Santa Monica Cop," Sam's jealousy and fondness for firearms give Charlie an opportunity to show how much he loves his best friend and number-one client; Hank's arsonist ex-girlfriend surprises him with a way for them to be together forever.