Cat (Lake Bell) and Lola (Erinn Hayes) break up with their boyfriends and spend an awkward night together trying to cheer each other up.

The staff find out about Lola's brain tumor; Briggs questions Glenn about his medical treatments; a boy who's aging too quickly comes in to the hospital; and Blake tries alternative medicine.

Blake recalls his past just as a new funny doctor arrives at the hospital; a visiting doctor offers his perspective on the staff.

Glenn obsesses over Cat's new boyfriend. Blake challenges the new doctor to a contest using laughter's power to heal.

Blake operates on Lola's fake tumor. Dr. Van Sydow performs surgery on the Chief.