All eyes are on Mackenzie Allen as she hosts her first official summit with the Russian President - which is threatened to be overshadowed by Nathan Templeton's plan to engineer a series of cabinet resignations to coincide with the summit. Templeton goes after Mac with a vengeance, vowing to run - and win - against her in the next presidential election. Meanwhile, as First Gentleman, Rod must host his first state dinner for the Russian President and his wife.
Mackenzie Allen, the 45-year old Independent Vice President, is about to enter a world in which no woman has ever stepped foot in before. While in attendance at a ceremony with her husband, Chief of Staff Rod Calloway, Mackenzie is given the startling news that President Bridges needs emergency brain surgery to treat a brain tumor. Mackenzie is given an additional shock when she is also informed that in the event the President doesn't make it through surgery, the party doesn't want her succeed him.
However, despite sexist insults from both the dying President and Speaker of the House Nathan Templeton, Mackenzie decides to fulfill her duty as Presidential successor and take her rightful place as Commander in Chief of the United States of America.